Human papillomavirus load and genotype analysis improves the prediction of invasive cervical cancer

Human papillomavirus (HPV)-based cervical screening is a globally recommended health policy. Different HPV types have different risk for cancer. For optimal screening, the sensitivity and specificity each type at viral loads should be known in setting. test results about 1 million samples analyzed during 2006 to 2014 were compared 319 women who had developed invasive cancer up 8.5 years later 1911 matched control women. Detection including low resulted markedly increased only 16 18. Testing 31, 33, 45 52 also prediction of cancer, but these viruses, detection load did not further increase sensitivity. 35, 39, 51, 56, 58, 59, 66 68 predicted occasional additional cases. HPV16/18 plus testing HPV31, >3000 copies/μL 86.5% cancers occurring within year after testing, similar 89.4% that by 14 types. By contrast, load-restricted greatly specificity: 6.3% healthy tested positive as 11.7% commonly screened today. Adequate sensitivity, with considerable specificity, can obtained HPV16/18/31/33/45/52, required HPV16/18.